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Product Description

This new edition of The American Psychiatric Association Publishing Textbook of Mood Disorders is a systematic and painstaking reconceptualization of its predecessor. Under new editorial direction and with a revised roster of expert contributors, the second edition is an utterly current, clinically competent, and comprehensive text that will become an instant classic. The book is structured for learning and easy reference, moving deftly from symptomatology and epidemiology to pathogenesis and on to somatic interventions, cognitive-behavioral interventions, and psychotherapy. The latest science on genetics and epigenetics, brain imaging, and neurobiology are also examined in depth. Critically important to the clinician is the section on management of mood disorders, which provides treatment guidelines for major depressive disorder and bipolar disorder, as well as information on understanding, and preventing, suicide in children, adolescents, and adults. Finally, perspectives are offered on depression among women, children, and geriatric patients, as well as on depression across cultures. Practicing psychiatrists, residents, and students alike will benefit from the book’s inclusive coverage.

Topics new to this edition include the following: – Treatment-resistant depression–its definition and approaches to its treatment–is addressed in a dedicated chapter that covers diagnostic accuracy, pseudoresistance, comorbidity, pharmacological management, adjunctive strategies, psychotherapy, neuromodulation, and novel and experimental therapies.- Investigational agents, most notably ketamine and its relatives, constitute an exciting frontier in the treatment of mood disorders, and the clinical application, routes of delivery, dosing, risks, and clinical trials are explored in a dedicated chapter that is both rigorous and thorough.- There is compelling evidence that childhood maltreatment (defined as exposure to emotional, physical, and sexual abuse and neglect before the age of 18 years) is a prominent risk factor for the development of mood disorders as well as for a pernicious course and poor treatment response in mood disorders. These findings, as well as the underlying neurobiological and environmental interactions that may contribute to the development of mood disorders, are examined thoroughly and thoughtfully.- As our understanding of immune function in mood disorders has grown, psychoneuroimmunology has emerged as a focus of study likely to make major contributions to clinical practice in the coming decades. The book updates readers on this promising area of research. Over the last decade, depression has emerged as the leading cause of disability worldwide, with significant attendant morbidity and mortality. The American Psychiatric Association Publishing Textbook of Mood Disorders equips clinicians and trainees with the knowledge they need to alleviate suffering in their patients with mood disorders.


The Textbook of Mood Disorders, Second Edition provides a comprehensive and detailed resource for understanding the presentation, biology and treatment of affective ilnesses across the lifespan and across populations. Authors synthesize useful and accessable information to guide both seasoned and novice psychiatric clinicians in when approaching patients with depression and bipolar disorders. I strongly recommend this text for anyone who needs an easy to read, up to date one stop shop for questions related to treating patients with mood disorders. –Steven Siegel, M.D., Ph.D., Chair and Chief of Clinical Services, Department of Psychiatry and the Behavioral Sciences, Franz Alexander Endowed Chair in Psychiatry, Professor of Psychiatry and the Behavioral Sciences and Population and Public Health Sci.

From the Back Cover

The new edition of The American Psychiatric Association Publishing Textbook of Mood Disorders shares a title with the previous edition, but little else. Three of the four editors are new to the volume, as are three of every four contributors, and this new team has created an authoritative, comprehensive, and evidence-based book that captures cutting-edge thinking on the epidemiology, pathogenesis, treatment, and management of mood disorders. Indeed, much has changed in the study and practice around mood disorders in the 16 years since the first edition. For example, reflecting growth in the field of psychoneuroimmunology, the book reviews the latest research on the role of the immune system in mood disorders. In addition, epigenetics—which is proving useful in understanding depression and bipolar disorder—is explored, giving psychiatrists and other mental health care providers the knowledge, they need to stay abreast of advances. While the book’s logical structure has been retained, each informative chapter offers fresh perspectives that rejuvenate and revivify the classic text. The second edition of The American Psychiatric Association Publishing Textbook of Mood Disorders is a book for a new generation of clinicians, trainees, and educators, and one that will earn its place next to other foundational, and indispensable, volumes.

About the Author

Charles B. Nemeroff, M.D., Ph.D., is the Matthew P. Nemeroff Professor and Chair of the Department of Psychiatry & Behavioral Sciences at the University of Texas, Austin, Dell Medical School.

Natalie Rasgon, M.D., Ph.D., is a Professor in the Department of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology at Stanford University School of Medicine and is also the Director of the Stanford Center for Neuroscience in Women’s Health and the Associate Dean of Academic Affairs.

Alan F. Schatzberg, M.D., is Kenneth T. Norris, Jr., Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California, where from 1991 to 2010 he was also the Chair of Psychiatry. He is currently Director of the Stanford Mood Disorders Center.

Stephen M. Strakowski, M.D., is Vice Dean of Research and Associate Vice President, Regional Mental Health, at the Dell Medical School, University of Texas at Austin. He is also Professor of Psychiatry & Behavioral Sciences, Psychology, and Educational Psychology at the University of Texas, Austin.


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